Andrew received his doctoral degree from the University of California, Los Angeles in 2002 between the Departments of Chemistry & Biochemistry and Molecular and Medical Pharmacology after completion of a B.S. in Biochemistry and Minor in Biotechnology from the Department of Chemistry & Biochemistry at California State University, Fullerton in 1995.


Andrew has worked on the stereoselective synthesis of inhibitors of the medically important enzyme fucosyltransferase V, an enzyme indirectly involved in such process as inflammation and metastasis. Andrew also has developed methodology for the use of Mass Spectroscopy for the analysis of enzyme kinetics and pioneered the first use of mass spectrometry for the kinetic characterization of enzyme inhibitors. Current work focuses on the use of mass spectrometry to study the molecular basis of rare genetic diseases and concurrently small molecule discovery for potential anti cancer agents.

A Listing of Dr. Andrew Norris' Publications

“A Concise and Stereoselective Synthesis of C-glycosyl Analoques of ?-L-Fucopyranosyl phosphate and ?-L-Rhamnopyranosyl phosphate.” Andrew J. Norris and Tatsushi Toyokuni. 1999, J. Carbohyd. Chem. 18, 1097–1105.


“Analysis of Enzyme Kinetics using Electrospray Ionization Mass Spectrometry and Multiple Reaction Monitoring: Fucosyltransferase V.” Andrew J. Norris, Julian P. Whitelegge, Kym F. Faull, and Tatsushi Toyokuni. (Accelerated Publication) Biochemistry 2001, 40, 3774–3779.


"Kinetic Characterization of Enzyme Inhibitors using Electrospray-Ionization Mass Spectrometry coupled with Multiple Reaction Monitoring.” Andrew J. Norris, Julian P. Whitelegge, Kym F. Faull, and Tatsushi Toyokuni. Anal. Chem. 2001, 73, 6024-6029.


“Inhibition Kinetics of Carba and C-Fucosyl Analogues of GDP-Fucose against Fucosyltransferase V: Implications for the Reaction Mechanism.” Andrew J. Norris, Julian P. Whitelegge, M. Jane Strouse, Kym F. Faull, and Tatsushi Toyokuni. Bioorg. Med. Chem. Lett 2004, 14, 571-573.


“Rapid Assay for Cerebroside Sulfate Activator as a Player in the Neurodegenerative Disorder Amyotrophic Leuko Dystrophy using ESI-MS/MRM.” Andrew J. Norris, Julian P. Whitelegge, Tatsushi Toyokuni, Claire Fluharty, Arvan Fluharty and Kym F. Faull. (Manuscript in preparation)


“A straightforward route to Isopolar Difluoromethylphosphonate Analogue of ?-L-fucopyranosyl phosphate" Joseph C. Walsh, Tanea Ysaguirre, Andrew J. Norris, and Tatsushi Toyokuni. (To be submitted to J. Carbohydrate Chem.).


“Characterization of a Recombinant Molecule Covalently Indistinguishable from Human Cerebroside-Sulfate Activator Protein. J.P. Whitelegge, V. Ahn, A.J. Norris, H. Sung, A. Waring, R.L. Stevens, C.B. Fluharty, G. Prive, K.F. Faull, and A.L. Fluharty. Cell. Mol. Bio. 2003, 49 (5):799-807.


“Borate-nucleotide complex formation depends on charge and phosphorylation state.” (2004). Danny H. Kim, Kym F. Faull, Andrew J. Norris and Curtis D. Eckhert. (in press).


“PC-SPES components inhibit the proliferation of breast cancer cells and endothelial cells.” Sartippour M.R., Norris A., Heber D., Hardy M., Seeram N., Rubio R., Maul R.S., Zhang L., and Brooks M.N. (2004). F.A.S.E.B. J., in press.