Kym F. Faull, Ph.D., Professor of Psychiatry & Biobehavioral Sciences,directs the UCLA Pasarow Mass Spectrometry Laboratory. He was born, raised and educated in Adelaide, South Australia. He completed a Ph.D. in Plant Physiology on plant hormones (gibberellins) at The University of Adelaide,then changed fields and began his experience in mass spectrometry with the detection and diagnosis of inherited diseases in children using GC/MS in the1970's working with Bethold Halpern (Wollongong, Australia) and David Danks (Melbourne, Australia). Since then he worked in neurochemistry, as a postdoc progressing through the staff ranks, at Stanford University School of Medicine principally on GC/MS of biogenic amines and related compounds, and later on FAB of neuropeptides. Since 1990 he has been at UCLA and the range of research accomplishments have expanded to embrace electrospray and MALDI of peptides, proteins, carbohydrates, lipids and other biomolecules. Dr. Faull derives un-ending pleasure from the inherent beauty and symmetry of chromatograms and mass spectra, and the rewarding experiences gained from producing these and comparable data sets.

A Partial Listing of Professor Faull's Publications

Faull, K.F., Wallace, W. and Nicholas, D.J.D. Nitrite oxidase and nitrate reductase in Nitrobacter Agilis. Biochem J, 113:449-455, 1969.


Faull, K.F., Coombe, B.G. and Paleg, L.G. Extraction and characterization of gibberellins from Hordeum vulgare L. seedlings. Aust J Plant Physiol, 1:183-189, 1974.


Faull, K.F., Coombe, B.G. and Paleg, L.G. Biosynthesis of gibberellins in barley and dwarf rice seedlings. Aust J Plant Physiol, 1:199-210, 1974.


Faull, K.F., Bolton, P., Halpern, B., Hammond, J., Danks, D.M., Hanel, R., Wilkinson, S.P., Wysocki, S.J. and Masters, P.L. Patient with a defect in leucine metabolism. N Engl J Med, 294:1013 (Letter to the Editor), 1976.


Faull, K.F., Gan, I., Halpern, B., Hammond, J., Im, S., Cotton, R.G.H., Danks, D.M. and Freeman, R. Metabolic studies on two patients with nonhepatic tyrosinemia using deuterated tyrosine loads. Ped Res, 11:631-637, 1977.


Weitz, C.J., Faull, K.F. and Goldstein, G. Synthesis of the skeleton of the morphine molecule by mammalian liver. Nature, 330:674-677, 1987.


Feistner, G.J., Hojrup, P., Evans, C.J., Barofsky, D., Faull, K.F. and Roepstorff, P. Mass spectrometric charting of bovine posterior/intermediate pituitary peptides. Proc Natl Acad Sci, 86:6013-6017, 1989.


Faull, K.F., Pascoe, N., Maddaluno, J.M., Greene, K.A., and Wiener, S. Passage from MHPG from plasma to CSF in a non-human primate. J. of Neuroscience Research, 27:533-540, 1990.


Stevens, R.L., Faull, K.F., Conklin, K.A., Green, B.N. and Fluharty, A.L. Porcine Cerebroside sulfate activator: further structural characterization and disulfide identification. Biochemistry, 32:4051-4059, 1993.


Feistner, G.F., Faull, K.F., Barofsky, D.F. and Roepstorff, P. Perspectives for mass spectrometric peptide and protein charting . J. Mass Spectrometry, 30:519-530, 1995.


Schneewind, O., Fowler, A. and Faull, K.F. Structure of the cell wall anchor of surface proteins in Staphlococcus aureus. Science 268:103-106, 1995.


Glasgow, B.J., Abduragimov A.R., Yusifov, T.N., Gassymov, O.K., Horwitz, J., Hubbell, W.L., and Faull, K.F. Characterization of the disulfide motif and secondary structure of tear lipocalins. Biochemistry, 37:2215-2225, 1998.


Kym F. Faull , Gottfried J. Feistner, Kenneth Conklin , Peter Roepstorff and Philip C. Andrews. Revised primary structures of rat pituitary g-LPH and b-endorphin. Neuropeptides, 32:339-349, 1998.


Whitelegge, J., P., Gunderson, C.B. and Faull, K.F. Electrospray-ionization mass spectrometry of intact intrinsic membrane proteins. Protein Science 7:1423-1430, 1998.


Faull, K.F., Higginson, J., Waring, A.J., To, T., Stevens, R.L., Whitelegge, J.P., Fluharty, C.B. and Fluharty, A.L. Disulfide connectivity in cerebroside sulfate activator is not necessary for biological activity but is necessary for tertiary structure. Archives of Biochemistry and Biophysics 376: 266-274, 2000.


le Coutre, J., Whitelegge, J.P., Gross, A., Turk, E., Wright, E.M., Kaback, H.R., and Faull, K.F. Proteomics on full-length membrane proteins using mass spectrometry. Biochemistry 39:4237-4242, 2000.


Norris, A.J., Whitelegge, J.P., Faull, K.F. and Toyokuni, T. Analysis of enzyme kinetics using electropsray ionization mass spectrometry and multiple reaction monitoring: Fucosyltranssfersae V. Biochemistry 40:3774-3779, 2001.


Gómez, S.M., Nishio, J.M., Faull, K.F. and Whitelegge, J.P. The chloroplast grana proteome defined by intact mass measurements from liquid chromatography mass spectrometry. Molecular and Cellular Proteomics, 1:46-59, 2002.


Whitelegge, J.P., Gómez, S.M., Aguilera, R., Roberson, R.W., Vermaas, W.F., Crother, T.R., Champion, C.I., Nally, J.E., Blanco, D.R., Lovett, M.A., Miller, J.N. and Faull, K.F. Identification of proteins and intact mass measurements in proteomics. Applied Genomics and Proteomics 1:13-22, 2002.

Ahn, V.E., Faull, K.F., Whitelegge, J.P., Fluharty, A.L. and Privé, G.G. Crystal structure of saposin B reveals a dimeric shell for lipid binding. Proc. Natl, Acad Sci (USA) 100:38-43, 2003.

Ahn, V.E., Faull, K.F., Whitelegge, J.P., Higginson, J. , Fluharty, A.L. and Prive, G.G. Expression, purification, crystallization and preliminary X-ray analysis of recombinant human saposin B. Protein Expression & Purification 27:186-193, 2003.

Bortz E., Whitelegge J.P., Jia Q., Zhou Z.H., Stewart J.P., Wu T.T., Sun R. Identification of Proteins Associated with Murine Gammaherpesvirus 68 Virions. J Virol. 77(24), 13425-13432, 2003.

Chen, F., Ng, P-S., Faull, K.F. and Lee, R.H. Cone photoreceptor bg-transducin: post-translational modification and interaction with phosducin. Investigative Opthalmology and Vision Research 44:4622-4629, 2003.

Gómez S.M., Bil' K.Y., Aguilera R., Nishio J.N., Faull K.F., Whitelegge J.P. Transit peptide cleavage sites of integral thylakoid membrane proteins. Mol Cell Proteomics 2 (10), 1068-85, 2003.

Kim, D., Marbois, B.N., Faull, K.F. and Eckhert, C.D. Esterification of borate with NAD+ and NADH as studied by ESI-MS and 11BNMR spectroscopy. Journal of Mass Spectrometry 38:632-640, 2003.

Kinzie S.D., Thevis M., Ngo K., Whitelegge J., Loo J.A., Abu-Omar M.M. Posttranslational Hydroxylation of Human Phenylalanine Hydroxylase Is a Novel Example of Enzyme Self-Repair within the Second Coordination Sphere of Catalytic Iron. J. Am. Chem. Soc. 125, 4710-1, 2003.

Shau H., Chandler G.S., Whitelegge J.P., Gornbein J.A., Faull K.F. and Chang H.R. Proteomic Profiling of Cancer Biomarkers. Briefings in Functional Genomics and Proteomics 2 (2), 147-158, 2003.

Slaughter N., Laux I., Tu X., Whitelegge J., Zhu X., Effros R., Bickel P., Nel A. The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation. Clin Immunol. 108(2): 138-51, 2003.

Weinglass, A.B., Whitelegge, J.P., Hu, Y., Verner, G.E., Faull, K.F. and Kaback, H.R. Exploiting mass spectrometry to elucidate substrate binding interactions in a membrane transport protein. EMBO Journal. 22:1467-1477, 2003.

Whitelegge, J.P., Gómez, S.M. and Faull, K.F. Proteomics of membrane proteins. Advances in Protein Chemistry. 65:271-307, 2003.

Whitelegge, J.P. HPLC of Intrinsic Membrane Proteins. Methods in Molecular Biology vol. 251, HPLC of Peptides and Proteins. M. Aguilar ed. 323-339, 2003

Whitelegge J.P., Kaback H.R., le Coutre J. Mass Spectrometry of the Lactose Permease. In Transmembrane Transporters. Receptor Biochemistry and Methodology Series. MW Quick, ed. 179-190, 2003.

Whitelegge J.P., Ahn V., Norris A.J., Sung H., Johnson J., Waring A., Stevens R.L., Fluharty C.B., Prive G., Faull K.F., Fluharty A.L. Characterization of a recombinant molecule covalently indistinguishable from human Cerebroside-Sulfate Activator Protein (CSAct or Saposin B). Cell. Mol. Biol. 49 (5), 799-807, 2003.

Whitelegge J.P. Thylakoid membrane proteomics. Photosynthesis Research 78, 265-277, 2003.

Woo, H.H., Faull, K.F., Hirsch, A.M. and Hawes, M.C. Altered life cycle in Arabidopsis plants expressing PsUGT1, a UDP-glucuronosyltransferase-encoding gene from pea. Plant Physiol. 133:538-548, 2003.

Crother, T., Nally, J., Blanco, D., Champion, C., Whitelegge, J.P., Lovett, T.C. Antigenic Composition of Borrelia burgdorferi during Infection in Rabbit Skin: A Temporal Analysis. Infection and Immunity, in the press.

Faham S., Yang D., Bare E., Yohannan S., Whitelegge J.P., Bowie J.U. Side-chain Contributions to Membrane Protein Structure and Stability. J Mol Biol. 335(1), 297-305, 2004.

Katz, J.E., Darren S. Dumlao, Jacob I. Wasserman, Michael E. Jung, Kym F. Faull, Steven Clarke. 3-Isopropylmalate is the Major Endogenous Substrate of the Saccharomyces cerevisiae TMT1 trans-Aconitate Methyltransferase. Biochemistry 43:5976-5986, 2004.

Nally, J.E., Whitelegge, J.P., Aguilera, R., Pereira, M.M., Blanco, D.R., Lovett, M.A. Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of Leptospira interrogans serovar Copenhageni. Proteomics, in the press.

Norris A.J., Whitelegge J.P., Strouse M.J., Faull K.F., Toyokuni T. Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism. Bioorg Med Chem Lett. 14(3):571-3, 2004.

Tu, X, Huang, A., Bae, D., Slaughter, N., Whitelegge, J.P., Crother, T., Nel, A. Use of Proteomics to characterize TCR-Associated Signaling Complexes In Lipid Rafts from a T-cell line. Journal of Proteome Research, in the press.

Yohannan S., Faham S., Yang D., Whitelegge J.P., Bowie J.U. The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors. Proc Natl Acad Sci U S A, 101(4):959-63, 2004.

Yohannan, S., Duan Yang, D., Faham, S., Boulting, G., Whitelegge, J.P., Bowie, J.U.Proline substitutions are not easily accommodated in a membrane protein. J. Mol. Biol, in the press.

WhiteleggeJP, Katz J, Pihakari K, Hale R, Aguilera R, Gómez SM, Faull KF, Vavilin, Vermaas W. Subtle modifcation of isotope ratio proteomics (SMIRP); a new strategy for expression proteomics. Phytochemistry, in the press.