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A Partial Listing of Dr. Whitelegge's Publications Jewess P, Whitelegge JP, Camilleri P, Bowyer JR. Synthesis of novel [C-14]-labelled
phenylureas bearing photoactive azido and diazirine groups as photoaffinity
labels for the herbicide binding site of photosystem-2. Journal of Labeled
Compounds and Radiopharmaceuticals 33, 655-669, 1993. Whitelegge JP, Koo D, Diner BA, Domian I, Erickson JM. Assembly of the Photosystem II Oxygen-evolving Complex Is Inhibited In psbA Site-directed Mutants of Whitelegge, JP. Covalent modification of Photosystem II reaction-center
polypeptides. In 'The Handbook of Photosynthesis', (M. Pessarakli, ed.),
Marcell Dekker,New York, pp. 241-256, 1996. Faull, K.F., Whitelegge, J.P., Waring, A.J., Stevens, R.L., To, T., Fluharty,
C.B., and Fluharty, A.L. Protease suseptibility of deglycosylated Cs activator
protein (Saposin B) (Abstr.). J. Neurochemistry: 69 (suppl):S192D, 1997. Gómez SM, Park JJ, Zhu J, Whitelegge JP, Thornber JP. Isolation
and Characterization of a novel Xanthophyll-rich Pigment-Protein Complex
from Spinach. In Photosynthesis: Mechanisms and Effects; Proceedings
of the 11th International Congress on Photosynthesis (G. Garab,
ed.), Kluwer Academic Publishers, Dordrecht, vol. I 353-356, 1998. Gundersen CB, Kohan S, Mastrogiacomo A, Whitelegge JP. Intrinsic Membrane
Association of Cysteine-string Proteins. FEBS Lett. 436, 85-91, 1998. Whitelegge, J.P., Faull, K.F., Penn, B., To, T., Waring, A.W., Fluharty,
C. and Fluharty, A. Investigation of the effect of protein oxidation upon
the lipid-binding activity of the cerebroside-sulffate activator protein
(Saposin B). In "New methods for the study of molecular aggregates"
NATO ASI Science Series, Kluwer, pp67-73, 1998. Whitelegge, J., P., Gunderson, C.B. and Faull, K.F. Electrospray-ionization
mass spectrometry of intact intrinsic membrane proteins. Protein Science
7:1423-1430, 1998. Blanco DR, Whitelegge JP, Miller JN, Lovett MA. Demonstration by mass
spectrometry that purified native Treponema pallidum rare outer membrane
protein 1 (Tromp1) has a cleaved signal peptide. Journal of Bacteriology
181, 5094-8, 1999. Faull, K.F., Higginson, J., Waring, A.J., To, T., Whitelegge, J.P., Stevens,
R.L., Fluharty, C and Fluharty, A.L. The hydrogen/deuterium exchange signature
of porcine cerebroside sulfate activator protein. Journal of Mass Spectrometry
35: 392-401, 1999. Faull, K.F., Whitelegge, J.P., Higginson, J., Waring, A.J., To, T., Johnson,
J., Krutchinsky, A.N., Standing, K.G., Stevens, R.L., Fluharty, C.B. and
Fluharty, A.L. Cerebroside sulfate activator protein (Saposin B): Chromatographic
and electrospray mass spectrometric properties. Journal of Mass Spectrometry:
34:1040-1054, 1999. Fluharty, A.L., Lombardo, C., Louis, A., Stevens, R.L., Whitelegge, J.,
Waring, A.J.., To, T., Fluharty, C.B. and Faull, K.F. Preparation of the
cerebroside sulfate activator (CSAct or Saposin B) from human urine. Molecular
Genetics and Metabolism: 68:391-402, 1999. Whitelegge, J.P., le Coutre, J., Lee, J.C., Engel, C.K., Privé,
G.G., Faull, K.F. and Kaback, H.R. Towards the bilayer proteome: Electrospray
ionization mass spectrometry of large intact membrane proteins. Proc.
Natl, Acad Sci (USA). 96:10695-10698, 1999. Whitelegge JP. Oxidative Damage to Proteins in Plants. In The Handbook
of Plant and Crop Stress, (M Pessarakli, ed.), Marcell Dekker, New York.
pp 555-568, 1999. Faull, K.F., Higginson, J., Waring, A.J., To, T., Stevens, R.L., Whitelegge,
J.P., Fluharty, C.B. and Fluharty, A.L. Disulfide connectivity in cerebroside
sulfate activator is not necessary for biological activity but is necessary
for tertiary structure. Archives of Biochemistry and Biophysics 376: 266-274,
2000. Faull, K.F., Johnson, J., Kim, M.J., To, T., Whitelegge, J.P., Stevens,
R.L., Fluharty, C.B. and Fluharty, A.L. Structure of the asparagine-linked
sugar chains of porcine kidney and human urine cerebroside sulfate activator
protein. Journal of Mass Spectrometry, 35:1416-1424, 2000. Gómez S.M., Nishio, J.N., Faull, K.F., Thornber, J.P., and Whitelegge,
J.P., The thylakoid membrane protein encoded by psbH has a second
phosphorylation site at Tyr30. Accepted/withdrawn at Plant Molecular
Biology, 2000. Suhr ST, Senut M-C, Whitelegge JP, Faull KF, Gage FH. Identities of Sequestered
Proteins in Aggregates from Cells with Induced Polyglutamine Expression.
Journal of Cell Biology 153, 283-294, 2000. Tjon, K, Faull, Kym and Whitelegge, J. Report on the effects of formic
acid on disulfide chemistry. UCLA Undergraduate Science Journal pp 132-136,
2000. Turk, E., Kim, O., le Coutre, J., Whitelegge, J.P., Eskandari, S., Lam,
J.T., Kreman, M., Zampighi, G., Faull, K.F. and Wright, E.M.. Molecular
characterization of Vibrio parahaemolyticus vSGLT: a model for sodium-coupled
sugar cotransporters. .Journal of Biological Chemistry, 275:25711-25716,
2000. Whitelegge, J.P., Penn, B., To, T., Johnson, J., Waring, A.J., Sherman,
M., Stevens, R.L., Fluharty, C.B., Faull, K.F., and Fluharty, A.L. Methionine
oxidation within the cerebroside sufate activator protein (CSAct or Saposin
B). Protein Science, 9;1618-1630, 2000. Fluharty, C.B., Johnson, J., Whitelegge, J.P., Faull, K.F. and Fluharty,
A.L. A comparative lipid binding study on the cerebroside sulfate avtivator
(saposin B). Journal of Neuroscience Research, 63:82-89, 2001. Norris, A.J., Whitelegge, J.P., Faull, K.F. and Toyokuni, T. Analysis
of enzyme kinetics using electropsray ionization mass spectrometry and
multiple reaction monitoring: Fucosyltranssfersae V. Biochemistry 40:3774-3779,
2001. Norris, A.J., Whitelegge, J.P.,Faull, K.F. and Toyokuni, T. Kinetic characterization
of enzyme inhibitors using electrospray-ionization mass spectrometry coupled
with multiple reaction monitoring. Analytical Chemistry, 73:6024-6029,
2001. Schroda, M., Vallon, O., Whitelegge, J.P., Beck, C.F., Wollman, F.-A.
Identification and Characterization of a Chloroplastic GrpE Homolog. The
Plant Cell 13, 2823-2839, 2001. Suhr, S.T., Senut, M-C., Whitelegge, J.P., Faull, K.F., Cuizon, D.M.,
and Gage, F.H. Identities of sequestered proteins in aggregates from cells
with induced polyglutamine expression. The Journal of Cell Biology 153:283-284,
2001. Whitelegge J.P., le Coutre J. Proteomics: Making Sense of Genomic Information
for drug discovery. American Journal of Pharmacogenomics 1, 29-35, 2001. Zhang H, Whitelegge JP, Cramer WA. Ferredoxin: NADP+ oxidoreductase is
a subunit of the chloroplast cytochrome b6f complex. J Biol Chem 276,
38159-38165,2001. Behnam K, Murray SS, Whitelegge JP and Brochmann E. Identification of
the molecular chaparone alpha B-crystallin in demineralized bone powder
and osteoblast-like cells. Journal of Orthopaedic Research 20, 1190-1196,
2002. Gómez, S.M., Nishio, J.M., Faull, K.F. and Whitelegge, J.P. The
chloroplast grana proteome defined by intact mass measurements from liquid
chromatography mass spectrometry. Molecular and Cellular Proteomics, 1:46-59,
2002. Nitao,L.K., Szent-Gyorgyi, A.G., Whitelegge, J.P., Faull, K.F. and Reisler,
E. Characterization of monofunctionally modified scallop S1. Biophysical
Journal 82: 1975 Part 2, 2002. Whitelegge JP, R. Aguilera, H. Zhang, R. Taylor, W.A Cramer. Full subunit
coverage liquid chromatography electrospray-ionization mass spectrometry
(LCMS+) of an Oligomeric Membrane Protein Complex: Cytochrome b6f Complex
from Spinach and the Cyanobacterium, M. laminosus. (2002). Molecular and
Cellular Proteomics 1, 816-827, 2002. Whitelegge JP. Plant proteomics: BLASTing out of a MudPIT. Proceedings
of the National Academy of Sciences U.S.A. 99, 11564-11566, 2002. Whitelegge, J.P., Kaback, H.R., le Coutre, J., Mass Spectrometry of
the Lactose Permease. In Transmembrane Transporters. Receptor Biochemistry and Methodology
Series. MW Quick, ed. 179-190, 2002. Whitelegge, J.P., Gómez, S.M., Aguilera, R., Roberson, R.W., Vermaas,
W.F., Crother, T.R., Champion, C.I., Nally, J.E., Blanco, D.R., Lovett,
M.A., Miller, J.N. and Faull, K.F. Identification of proteins and intact
mass measurements in proteomics. Applied Genomics and Proteomics 1:13-22,
2002. Ahn, V.E., Faull, K.F., Whitelegge, J.P., Fluharty, A.L. and Privé,
G.G. Crystal structure of saposin B reveals a dimeric shell for lipid
binding. Proc. Natl, Acad Sci (USA) 100:38-43, 2003. Ahn, V.E., Faull, K.F., Whitelegge, J.P., Higginson, J. , Fluharty, A.L.
and Prive, G.G. Expression, purification, crystallization and preliminary
X-ray analysis of recombinant human saposin B. Protein Expression &
Purification 27:186-193, 2003. Bortz E., Whitelegge J.P., Jia Q., Zhou Z.H., Stewart J.P., Wu T.T., Sun R. Identification
of Proteins Associated with Murine Gammaherpesvirus 68 Virions. J Virol. 77(24), 13425-13432, 2003. Gómez S.M., Bil' K.Y., Aguilera R., Nishio J.N., Faull K.F., Whitelegge J.P. Transit peptide
cleavage sites of integral thylakoid membrane proteins. Mol Cell Proteomics 2 (10), 1068-85, 2003. Kinzie S.D., Thevis M., Ngo K., Whitelegge J., Loo J.A., Abu-Omar M.M. Posttranslational
Hydroxylation of Human Phenylalanine Hydroxylase Is a Novel Example of Enzyme Self-Repair
within the Second Coordination Sphere of Catalytic Iron. J. Am. Chem. Soc. 125, 4710-1, 2003. Shau H., Chandler G.S., Whitelegge J.P., Gornbein J.A., Faull K.F. and Chang H.R. Proteomic
Profiling of Cancer Biomarkers. Briefings in Functional Genomics and Proteomics 2 (2), 147-158, 2003. Slaughter N., Laux I., Tu X., Whitelegge J., Zhu X., Effros R., Bickel P., Nel A. The
flotillins are integral membrane proteins in lipid rafts that contain TCR-associated
signaling components: implications for T-cell activation. Clin Immunol. 108(2): 138-51, 2003. Weinglass, A.B., Whitelegge, J.P., Hu, Y., Verner, G.E., Faull, K.F.
and Kaback, H.R. Exploiting mass spectrometry to elucidate substrate binding
interactions in a membrane transport protein. EMBO Journal. 22:1467-1477,
2003. Whitelegge, J.P., Gómez, S.M. and Faull, K.F. Proteomics of membrane proteins. Advances in Protein Chemistry. 65:271-307, 2003. Whitelegge, J.P. HPLC of Intrinsic Membrane Proteins. Methods in Molecular
Biology vol. 251, HPLC of Peptides and Proteins. M. Aguilar ed. 323-339, 2003 Whitelegge J.P., Kaback H.R., le Coutre J. Mass Spectrometry of the Lactose
Permease. In Transmembrane Transporters. Receptor Biochemistry and Methodology
Series. MW Quick, ed. 179-190, 2003. Whitelegge J.P., Ahn V., Norris A.J., Sung H., Johnson J., Waring A., Stevens R.L., Fluharty C.B.,
Prive G., Faull K.F., Fluharty A.L. Characterization of a recombinant molecule
covalently indistinguishable from human Cerebroside-Sulfate Activator Protein (CSAct
or Saposin B). Cell. Mol. Biol. 49 (5), 799-807, 2003. Whitelegge J.P. Thylakoid membrane proteomics. Photosynthesis Research 78, 265-277, 2003. Crother, T., Nally, J., Blanco, D., Champion, C., Whitelegge, J.P., Lovett, T.C. Antigenic
Composition of Borrelia burgdorferi during Infection in Rabbit Skin: A Temporal Analysis.
Infection and Immunity, in the press. Faham S., Yang D., Bare E., Yohannan S., Whitelegge J.P., Bowie J.U. Side-chain
Contributions to Membrane Protein Structure and Stability. J Mol Biol. 335(1), 297-305, 2004. Nally, J.E., Whitelegge, J.P., Aguilera, R., Pereira, M.M., Blanco, D.R., Lovett, M.A.
Purification and proteomic analysis of outer membrane vesicles from a clinical isolate of
Leptospira interrogans serovar Copenhageni. Proteomics, in the press. Norris A.J., Whitelegge J.P., Strouse M.J., Faull K.F., Toyokuni T. Inhibition
kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V:
implication for the reaction mechanism. Bioorg Med Chem Lett. 14(3):571-3, 2004. Tu, X, Huang, A., Bae, D., Slaughter, N., Whitelegge, J.P., Crother, T., Nel, A. Use of
Proteomics to characterize TCR-Associated Signaling Complexes In Lipid Rafts from a T-cell
line. Journal of Proteome Research, in the press. Yohannan S., Faham S., Yang D., Whitelegge J.P., Bowie J.U. The evolution of transmembrane
helix kinks and the structural diversity of G protein-coupled receptors. Proc Natl Acad
Sci U S A, 101(4):959-63, 2004. Yohannan, S., Duan Yang, D., Faham, S., Boulting, G., Whitelegge, J.P., Bowie, J.U.Proline
substitutions are not easily accommodated in a membrane protein. J. Mol. Biol, in the press. WhiteleggeJP, Katz J, Pihakari K, Hale R, Aguilera R, Gómez SM, Faull KF, Vavilin, Vermaas W.
Subtle modifcation of isotope ratio proteomics (SMIRP); a new strategy for expression proteomics.
Phytochemistry, in the press. |