Funded research

Current:

Organ-Specific NRF2-Mediated Protein Signatures of Radiation Exposure & Tissue Damage.

NIH/NIAID R01AI101888
PI: Julian Whitelegge
07/01/12 – 06/30/18
This project seeks to discover/validate biomarkers of radiation exposure and organ-specific damage in mice. MPI with William McBride (Radiation Oncology) and Joseph Loo (Chemistry & Biochemistry)

Completed:

Microfluidics for High-Throughput HDX-MS.

NIH/NIGMS R21GM104593
PI: Julian Whitelegge
07/01/12 – 05/31/16
The goal of this project is to couple a microfluidics device configured for hydrogen-deuterium exchange with electrospray-ionization mass spectrometry for high-throughput screening.

Proteomic approaches to protein fatty acylation.

NIH/NCRR R21RR023132
PI: Julian Whitelegge
08/15/09 – 7/31/11
The work will define technology for enrichment, purification and mass spectrometry of fatty acylated peptides from complex biological samples.

Subtle Modification of Isotope Ratio Proteomics, an Integrated Strategy for Expression Proteomics

NIH/NCRR R21RR021913
PI: Julian Whitelegge
03/22/08 – 02/28/11
This proposal seeks to develop isotope-ratio proteomics as a platform for human expression and turnover proteomics.

Peptide Biomarkers of drug exposure: from brain microdialysate to plasma.

NIH/NIDA R21DA027499
PI: Nigel Maidment
09/01/09 – 08/31/12
The proposed work will look for peptide biomarkers of previous drug exposure in brain microdialysate and plasma using high sensitivity mass spectrometry. MPI with Niall Murphy and Julian Whitelegge.

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Metabolomic and Proteomic Analyses