Ongoing projects & collaborations

Professor Julian Whitelegge

  • Bottom-up proteomics in various diseases and systems
  • Membrane protein structure and function
  • Top-down proteomics of membrane and other proteins
  • Proteomics in diabetes research
  • Biomarkers of radiation exposure
  • Proteomic biomarker investigations in breast cancer
  • Protein misfolding and neurodegenerative disease
  • Mechanisms of SOD1-linked amyotrophic lateral sclerosis
  • Microfluidics for high-throughput hydrogen-deuterium exchange of proteins
  • Pharmacokinetics of new potential drugs

Laboratory Projects

  • Glutathione turnover in various diseases and systems
  • The role of sulfated lipids in egg fertilization
  • Protein misfolding in pancreatitis and alcohol abuse
  • Metabolomic profiling in traumatic brain injury
  • Biomarker investigations in:
    • Kidney rejection
    • Prostate cancer
    • Alzheimer’s disease
  • The role of de novo and salvage DNA synthesis in cancer
  • Organic residue analysis in ancient archeological samples
  • The translational accuracy in microbial protein biosynthesis
  • Glutathionylation of a Yersinia pestis protein
  • Lipid profiling in atherosclerosis and other diseases
  • Pharmacokinetics of new potential drugs