Representative instruments

Thermo Q Exactive Plus Orbitrap LC-MS

The QE Plus is a hybrid mass spectrometer that combines the selectivity of a quadrupole with the high resolution of a Orbitrap, improving quantification of low abundance ions within complex matrices over ion trap instruments. In addition to standard modes of operation, this instrument also features data-independent acquisition, and parallel reaction monitoring modes which deliver reproducible quantitation with complete qualitative confidence.

Thermo Q Exactive hybrid quadrupole-Orbitrap GC-MS

The GC-Orbi is used for the identification and quantification of small molecules at high chromatographic and mass resolution and high sensitivity. This instrument is capable of automated liquid and headspace gas sampling, and solid phase microextractions (SPME) for MS analysis with electron or chemical ionization (EI, CI). In service as of December 2015.

Thermo LTQ Orbitrap XL LC-MS (2)

The Orbitraps employ a hybrid system that combines the speed and sensitivity of a linear ion-trap with the high-resolution and mass accuracy of an Orbitrap. These instruments are utilized primarily for bottom-up proteomics and metabolomics analysis.

Agilent 6460 Triple Quad LC-MS (3)

The Triple Quads deliver robust, accurate quantification of analytes present at low levels through selected reaction monitoring (SRM/MRM). These instruments are regarded as the gold standard for precise quantitation, and an ideal choice for rapid separations and high-throughput analysis of diverse compound types.

Thermo LCQ Deca XP Plus Ion Trap LC-MS

The LCQ is a quadrupole ion trap offering ruggedness and reliability in general use, including analyzing drugs, metabolites, and proteins. Its MSn capability makes it a unique tool for the structural elucidation of complex molecular structures.

Applied Biosystems Voyager-DE STR MALDI-TOF

The “DEath STaR” is used for matrix-assisted laser desorption ionization (MALDI) which is an ionization method that generates low charge state ions (often singly charged species), allowing the measurement of fragile structures from small (metabolites, drugs) to large molecules (protein, nucleic acids, polymers). This ionization method is tolerant of a wide range of adulterants that are frequently used in biochemical sample preparation, many of which would otherwise interfere with electrospray ionization.

Hewlett Packard 1090 Series II HPLC-UV/Vis

The 1090 is used for robust automatic separation and detection of complex mixtures. It is commonly used for preparatory fractionation or purification, and quantification of UV-Vis detectable compounds.